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化学化工导师

周怡波

发布日期:2023年06月26日 来源: 作者:

姓名:周怡波

职称/职务:副教授

       

性别:

最高学历:博士

系室:化学系

邮箱:yibozhou@163.com

教育背景:

2013.09 – 2017.12        湖南大学化学化工学院         分析化学/博士

2009.09 – 2012.06        湖南大学化学化工学院         物理化学/硕士

2005.09 – 2009.06        吉首大学化学化工学院         化学/学士

科研情况:

近5年科研项目:

1、国家自然科学基金青年基金项目,21804012,“胞浆蛋白辅助荧光放大高灵敏检测及荧光成像成纤维细胞活化蛋白,2019/01-2021/12,已结题,主持。

2、湖南省自然科学基金青年基金项目,2019JJ50634,金属离子辅助荧光放大纳米探针构建及其在炎症性肠病成像中的应用,2019/01-2021/12,已结题,主持。

3、湖南省教育厅优秀青年基金项目,23B0308,ATP辅助信号放大荧光成像抑郁症相关单胺氧化酶A,2023/10-2025/10,在研,主持。

4、长沙市自然科学基金,kq2208216ATP多价结合驱动信号放大策略的构建及肝硬化成像分析,2023/01-2024/12,在研,主持。

5、区域遗传性出生缺陷防控研究湖南省重点实验室开放基金重点项目,HPKL2023009,类酶催化荧光放大体系的构建及胚胎Zn2+成像应用研究,2023/10-2025/10,在研,主持。

6、化学生物传感与计量学国家重点实验室开放基金项目,2021018,基于H-聚集的零背景荧光信号放大纳米探针的构建及胚胎多硫化氢成像研究,2022/04-2024/04,在研,主持。

近5年科研论文:

(1)Yibo Zhou, Zhengxuan GuChanghui LiuSheng Yang,* Xiaofei MaQiaoshu ChenYanli LeiKe QuanJuewen LiuZhihe Qing,* Ronghua Yang.* A Polymeric Nanobeacon for Revealing Hydrogen Polysulfides Fluctuation during Fertilization and Embryonic Development. Angew. Chem. Int. Ed., 2022, 61, e202114504. (A1, IF=16.6, VIP论文)

(2)Ni Zeng, Xiuhong Guan, Xiaowen Liu, Huiqiu Shi, Nan Li, Ruimeng Yang, Yibo Zhou*. Fibroblast activation protein-sensitive polymeric nanobeacon for early diagnosis of renal fibrosis. Biosensors and Bioelectronics, 2024, 253, 116144. (A1, IF=12.6)

(3)Huihong Liu, Xianqing Zeng, Honghui Yin, Jing Chen, Wenzhi Xie, Guoqiang Zhou, Guojiang Mao, Yibo Zhou*, Sheng Yang*. A pH-switchable azo-based fluorescence reporter for lysosome-confined visualization of hypoxia status. Sensors & Actuators: B. Chemical., 2023, 381, 133431. (A1, IF=8.4)

(4)Yibo Zhou*, Shan Hu, Hongwen Liu, Xinyue Xiao, Weiju Chen, Sheng Yang, Huiqiu Shi, Zhenxuan Gu, Junbin Li, Ronghua Yang* and Zhihe Qing*. Activity-Independent Enzyme-Powered Amplification for Improving Signal Stability and Fidelity in Biosensing. Chemical & Biomedical Imaging, 2024, 2, 4, 304-312 (A1, 封面论文)

(5)Yibo Zhou*, Jun Zhang, Shuanghong Sun, Weiju Chen, Yuping Wang, Huiqiu Shi, Ronghua Yang,* and Zhihe Qing*. Amplified biosensor powered by endogenous molecules for intracellular fluorescence imaging. Analytical Chemistry, 2024, 96, 20, 8078-8090. (A1, IF=7.4)

(6)Junbin Li, Na Wang, Mengyi Xiong*, Min Dai, Cheng Xie, Qianqian Wang, Ke Quan, Yibo Zhou*, and Zhihe Qing*. A Reaction-Based Ratiometric Bioluminescent Platform for Point-of-Care and Quantitative Detection Using a Smartphone, Analytical Chemistry, 2023, 95, 18, 7142-7149. (A1, IF=7.4)

(7)Yibo Zhou, Xiaofei Ma, Shan Hu, Sheng Yang, Jingru Guo, Junbin Li, Yue-Fei Zhang, Juewen Liu, Zhihe Qing*, and Ronghua Yang*. Rigidity-Dependent Emission: Inspired Selection of an ATP-Specific Polyvalent Hydrogen Binding-Lighted Fluorophore for Intracellular Amplified Imaging, Analytical Chemistry, 2023, 95, 21, 8318-8324. (A1, IF=7.4)

(8)Taoyun Wang, Xu Huang, Sheng Yang, Shan Hu, Xianglan Zheng, Guojiang Mao, Yi Li*, Yibo Zhou.* Monitoring H2S fluctuation during autophagic fusion of lysosomes and mitochondria using a lysosome-targeting fluorogenic probe, Analytica Chimica Acta, 2023, 1265, 341356. (A1, IF=6.2)

(9)Yibo Zhou*, Hao Dong, Zhengxuan Gu, Sheng Yang, Minzhi Ouyang, Zhihe Qing, Xiaofei Ma, Shan Hu, JunBin Li, and Ronghua Yang*. Self-Immolative Dye-Doped Polymeric Probe for Precisely Imaging Hydroxyl Radicals by Avoiding Leakage. Analytical Chemistry, 2021, 93, 12944-12953. (A1, IF=7.4)

(10)Yibo Zhou, Keyi Yin, Hao Dong, Sheng Yang*, JunBin Li, Jinqiu Luo, Yi Li, and Ronghua Yang*. Long-Lasting Bioluminescence Imaging of the Fibroblast Activation Protein by an Amphiphilic Block Copolymer-Based Probe. Analytical Chemistry, 2021, 93, 3726-3732. (A1, IF=7.4)

(11)Yibo Zhou, Sheng Yang*, Jingru Guo, Hao Dong, Keyi Yin, Wei Tao Huang, and Ronghua Yang*. In Vivo Imaging of Hypoxia Associated with Inflammatory Bowel Disease by a Cytoplasmic Protein-Powered Fluorescence Cascade Amplifier. Analytical Chemistry, 2020, 92, 5787-5794. (A1, IF=7.4)

(12)Yibo Zhou, Sheng Yang*, Yue Xiao, Zhen Zou, Zhihe Qing, Juewen Liu, and Ronghua Yang*. Cytoplasmic Protein-Powered In Situ Fluorescence Amplification for Intracellular Assay of Low-Abundance Analyte. Analytical Chemistry, 2019, 91, 15179-15186. (A1, IF=7.4)

科研奖励:

1. 湖南省自然科学二等奖

2. 皇冠welcome体育“湖湘学者”青年英才

3. 湖南省化学化工学会第十八届青年化学化工奖

4. 湖南省优秀硕士论文指导教师

近5年申请专利:

1. 周怡波尹柯仪杨荣华一种能长时间成像FAP的生物发光探针及其应用, 2022-9-13, 中国, ZL2020 1 0860240.4

2. 周怡波胡山杨荣华一种响应ATP的荧光染料及其制备方法和应用, 2024-1-3, 中国, ZL 2022 1 1374678.7

3. 周怡波,胡山,肖新月,卿志和。一种响应羧酸酯酶荧光染料及其制备方法及应用,2023-12-15, 中国, 202311730996.7

教学情况:

主讲本科生《仪器分析》、《分析化学实验》、研究生《分子光谱学》《化学生物学》等课程。

 近5年教研项目及教改论文:

1、学位与研究生教学改革研究项目,基于大型科研仪器的专业学位研究生实践课程改革,2023/12-2025/12,在研,主持

2、“激光扫描共聚焦显微镜在本科实验教学应用初探“,山东化工:2021,50,212.

3、“理工科院校分析测试中心发展及思考-以皇冠welcome体育为例“,广东化工,2021,48,273.

研究生招生

  本课题组开展生化传感相关领域基础和应用研究,优秀毕业生可推荐到知名大学或研究所攻读博士学位。欢迎具有生物、化学、化工等背景的有志同学报考研究生!


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